Genetics

TDP-43 aggregation drives loss of UNC13A, a risk gene for ALS & FTD

de novo proteins generated from cryptic exon translation in ALS & FTD

APOE-targeted epigenome therapy for Alzheimer’s disease

Ensuring the safety of epigenome therapies in the treatment of Alzheimer’s disease

Ongoing and future efforts in functional genomics in Alzheimer’s disease

Can the APOEε4 genotype contribute to tau pathology progression?

Personalized approach to dementia prevention and treatment

Is there a genetic basis for the rate of progression of Alzheimer’s disease?

Role of ancestry in the predictivity of genetic data

Deep molecular profiling to identify new genetic variants and drug targets in Alzheimer’s disease

Combining genetics and molecular biomarkers for Alzheimer’s disease prognostication

Diverse ancestral populations and the ADSP

Importance of ancestral background in conferring risk for genetic factors in Alzheimer’s disease

Disparate roles of activated microglia across the Alzheimer’s spectrum

The Alzheimer’s Disease Sequencing Project Functional Genomics Consortium

Projects of the Alzheimer’s Functional Genomics Consortium: iPSC modelling and multi-omics