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A metallic probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide has identified a binding site that could facilitate better drugs to treat Alzheimer's disease. When the probe is illuminated, it catalyzes…
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Scientists have characterized a new class of drugs as potential therapeutics for Alzheimer's disease and discovered a piece in the puzzle of how they would work.
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A team of researchers reveals a mechanism that can explain how even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models.
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While memory loss is an early symptom of Alzheimer's disease, its presence doesn't mean a person will develop dementia. A new study has found a clinically useful way to predict who won't develop Alzheimer's disease, based on patients' awareness of…
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Scientists studying the molecular roots of Alzheimer's disease have encountered a good news/bad news scenario. The bad news is that in the early stages of the disease, high-risk TREM2 variants can hobble the immune system's ability to protect the brain…
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Stroke patients with dementia treated with intravenous thrombolysis using powerful clot-busting drugs are at no higher risk of brain haemorrhage or death than other patients receiving the same treatment, a new study reports.
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A new research report calls for a change in approach in the treatment of psychosis in dementia, to find alternatives to highly damaging antipsychotics.
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A new study ranking the safety and effectiveness of four drugs taken to enhance concentration, memory, alertness and moods, found that donepezil was most likely to effectively improve cognition in patients with Alzheimer's disease.
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With disease-modifying treatment trials for Alzheimer's disease (AD) currently unsuccessful and only medications to treat symptoms available, what now? A leading neuroscientist has developed the
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No evidence has been found to support the idea that personality changes begin before the clinical onset of mild cognitive impairment (MCI) or dementia, a new and comprehensive study reports.
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People with both high and low levels of magnesium in their blood may have a greater risk of developing dementia, according to a study.
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A new role has been identified for the major Alzheimer's risk factor ApoE4, suggesting that targeting the protein may help treat the disease. Researchers show that ApoE4 exacerbates the brain damage caused by toxic tangles of a different Alzheimer's-associated protein:…
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Physical aggression among people with dementia is not unusual. A study showed that one-third of patients with the diagnosis Alzheimer’s disease or frontotemporal dementia were physically aggressive towards healthcare staff, other patients, relatives, animals and complete strangers. This manifestation of…
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A new study shows that hypometabolism in the medial prefrontal areas is specifically associated with Alzheimer's disease-related nutritional problems, and decrease in fat mass may have a key role.
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Scientific literature in recent years has focused extensively on one genetic risk factor for Alzheimer's disease, the ApoE4 gene variant. A recent study raises flags that scientists should investigate another important player, the TOMM40 gene.
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A set of simple steps that promote heart health, called Life's Simple 7, can also foster ideal brain health, an expert panel says. Improving your health status with Life's Simple 7 may reduce the risk of dementia caused by strokes,…
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In the largest and most conclusive study of its kind, researchers have analyzed blood samples to create a novel and non-invasive way of helping to diagnose Alzheimer's disease and distinguishing between different types of neurodegenerative disorders. Following this breakthrough discovery,…
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Stress, fatigue, and feeling like your memory is failing you. These are the symptoms of a growing group of patients. Result – They may need help, but they are rarely entering the initial stages of dementia.
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Alzheimer’s disease can lead to several widely divergent symptoms and, so far, its various expressions have mainly been observed through the behavior and actions of patients. Researchers have now produced images showing the changes in the brain associated with these…
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Changes in how humans map their surroundings and construct and follow directions as they age have been understudied compared to effects on memory and learning. However, age-related declines in navigational ability are independent of those more well-known cognitive downturns, and…
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