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Canola oil is one of the most widely consumed vegetable oils, yet little is known about its health effects. Now, a study links canola oil consumption in the diet with worsened memory, worsened learning ability and weight gain in mice…
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About 15 million Americans will have either Alzheimer's dementia or mild cognitive impairment by 2060, up from approximately 6.08 million this year. The findings highlight the need to develop preventive measures that could slow the progression of the disease in…
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Using a bioinformatics and experimental approach, scientists have found that rendering mitochondria resistant to damage can halt diseases caused by amyloid toxicity, such as Alzheimer's disease.
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People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer's disease. Now, researchers have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer's protein…
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Researchers report on the first large-scale longitudinal imaging study to evaluate BACE1 inhibition with micro-PET in mouse models of Alzheimer's disease. PET imaging has been established as an excellent identifier of the amyloid plaque and tau tangles that characterize Alzheimer's…
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Proteins are huge molecules whose function depends on how they fold into intricate structures. To understand how these molecules work, researchers use computer modeling to calculate how proteins fold. Now, a new algorithm can accelerate those vital simulations, enabling them…
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A new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease. The molecule, called anle138b, works by stopping toxic ion flow in the brain that is known to trigger nerve cell death. Scientists envision…
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Making an AD mouse model that incorporates both A-beta and tau pathologies in a more AD-relevant context has been greatly sought after but difficult to accomplish. Now, researchers have done that and it's a big step for AD research, which…
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A simple new tool that tracks cognitive performance in adults aims to help physicians identify people who may be on the path to Alzheimer's disease or another form of dementia.
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People who have a high body mass index (BMI) are more likely to develop dementia than those with a normal weight, according to a new study.
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There is no evidence that accumulation in the brain of the element gadolinium speeds cognitive decline, according to a new study.
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Marriage may lower the risk of developing dementia, concludes a synthesis of the available evidence.
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There is increasing evidence that the level of delirium in post-surgical patients is associated with the level of later cognitive decline in those same patients.
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The health advantages of high-intensity exercise are widely known but new research points to another major benefit: better memory. The findings could have implications for an aging population which is grappling with the growing problem of catastrophic diseases such as…
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Scientists have revealed that elderly people with mild cognitive impairment (MCI) have a particularly weakened ability to memorize human faces in the short term when compared to healthy elderly people. MCI patients also had a different gaze behavior when trying…
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Alzheimer's disease is caused by tangles in the brain made up of malfunctioning aggregated Tau proteins. Scientists have discovered a new toxic form of Tau that forms as a result of its interaction with cell membranes. The research provides novel…
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Scientists have concluded that developing dementia or Alzheimer's disease (the most common form of dementia) did not appear to be linked to taking proton pump inhibitors (PPIs).
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In a comprehensive analysis of samples from 107 aged human brains, researchers have discovered details that will help researchers better understand the biological bases for Alzheimer's disease and dementia in older populations.
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A unique model for the biology of Alzheimer's disease (AD) is now being described by researchers, which may lead to an entirely novel approach for treating the disease.
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Benzodiazepine and related drug use is associated with a 40 percent increase in mortality among persons with Alzheimer's disease, according to a new study.
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