Our knowledge of molecular mechanisms of dementia has greatly improved, but what are the next steps? Here, Nigel Hooper, PhD, of the University of Manchester, Manchester, UK, discusses how our understanding of dementia has changed and forecasts where he sees the field moving, highlighting the need to determine how different pieces of knowledge fit together. Prof. Hooper also addresses the biggest challenge to overcome in dementia research. This video was recorded at the Alzheimer’s Research UK Conference 2018, held in London, UK.