ARUK 2022 | Targeting the glymphatic system to treat Alzheimer’s disease

Ian Harrison, PhD, UCL Centre for Advanced Biomedical Imaging, University College London, London, UK, discusses the potential of the glymphatic system in treating Alzheimer’s disease, due to its ability to remove proteins prone to aggregation in the brain. One future avenue of research is attempting to speed up the glymphatic system, with the aim of reducing the protein accumulation. Dr Harrison explains how lifestyle changes, such as exercise, and pharmacological interventions, such as agents targeting aquaporin-4, may positively affect the glymphatic system. This interview took place at the Alzheimer’s Research UK Conference 2022 in Brighton, UK.