Etienne de Villers-Sidani, MD from the Montreal Neurological Institute, Montreal, Canada talks to us about the complicated nature of cognitive training. It is still not clearly understood how this therapy is able to benefit patients, and Dr de Villers-Sidani explains how uncovering this is key to providing personalized treatment tailored to each patient. This interview was recorded at the 2017 Alzheimer’s Association International Conference (AAIC) in London, UK.