Maya Koronyo-Hamaoui, PhD, Cedars-Sinai Medical Center, Los Angeles, CA, describes her group work on retinal vasculopathy in Alzheimer’s disease presented at the Alzheimer’s Research UK (ARUK) Conference 2021. The group analyzed paired samples of brain and retina of patients, available from the University of Southern California (USC) Alzheimer Disease Research (ADR) biobank. Cellular and molecular changes in the vessels previously observed in the brain of patients could also be found in the retina, including in early stages cases of the disease. These changes are associated with pathological hallmarks of Alzheimer’s disease, such as the accumulation of amyloid beta. They can help predict changes in the brain related to both pathological and cognitive status of Alzheimer’s disease.
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