Inflammation in Alzheimer’s disease: mechanisms and implications

“Neuroinflammation is associated with Alzheimer’s disease progression. In this video, recorded at the Alzheimer’s Association International Conference (AAIC) 2018, held in Chicago, IL, Roisin McManus, PhD, of the German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, discusses the mechanisms associated with neuroinflammation. She explains how amyloid plaques can activate inflammasomes in brain cells, which triggers the release of inflammatory compounds such as ASC specks and IL-1β, which in turn may lead to increased amyloid deposition. She also discusses her work combining genetically inflammasome-depleted cells with pharmaceutical inflammasome inhibitors to act as a novel therapy in cell culture and in vivo models.

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