Christian J. Camargo, MD, University of Miami Miller School of Medicine, Miami, FL, highlights the excitement surrounding research into synaptic function and recovery as a key player in cognition. Growing evidence suggests that synaptic plasticity, density, and function are highly relevant both in normal cognitive aging and pathological cognitive decline. In this way, interventions targeted towards improving synaptic function may be valuable in numerous populations, including Alzheimer’s disease and age-related cognitive decline independent of pathology. Dr Camargo and his team are currently trialing the use of an oral multi-nutrient combination designed to support the formation and function of neuronal membranes and synapses. By supplementing key precursors and cofactors for phospholipid biosynthesis (omega-3 fatty acids, uridine, and choline), it is hoped this intervention may have a beneficial impact on synaptic plasticity and dendritic spine loss in patients with age-related cognitive decline. This interview took place at the Alzheimer’s Association International Conference (AAIC) 2022 in San Diego, CA.
This work was funded by the American Academy of Neurology McKnight Clinical Translational Research Scholarship