Educational content on VJDementia is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ARUK 2023 | Microglia phenotypic transitions in neurodegenerative diseases

Amy Lloyd, PhD, University of Dundee, Dundee, shares an overview of her research that established the importance of microglia necroptosis and repopulation for efficient remyelination. It is known that a transition from pro-inflammatory microglia activation to a pro-regenerative microglia state is key to initiate remyelination. When this transition fails, remyelination is impaired: a major cause of neurodegeneration in several central nervous system disorders, including multiple sclerosis (MS). Dr Lloyd’s study investigated the mechanisms underlying this transition, identifying pro-inflammatory microglia necroptosis and repopulation as a driver of remyelination. Dr Lloyd comments on the wider implications of this study, highlighting the disparate roles of microglia at different timepoints during Alzheimer’s disease development and progression. It is hoped that unbiased proteomic analyses could lead to a deeper understanding of what drives these microglia phenotypic changes in Alzheimer’s disease to reveal novel targets. This interview took place at the Alzheimer’s Research UK (ARUK) Conference 2023 in Aberdeen, UK.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.