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ARUK 2021 | iPSC models of neurodegenerative disease

Selina Wray, PhD, University College London, London, UK, discusses the advantages of using induced pluripotent stem cells (iPSC) models, such as the possibility to make patient-specific models. iPSC can be generated from patients with a genotype and/or phenotype of interest and subsequently be used to generate cerebral organoids. Prof. Wray discusses the use of 2D cortical neurons and 3D cerebral organoids to model neurodegenerative disease, including their opportunities and challenges. This interview took place during the Alzheimer’s Research UK (ARUK) Conference 2021.