Christos Lisgaras, PhD, NYU Langone Health and The Nathan S. Kline Institute Center for Dementia Research, New York, NY, presents novel data showing the occurrence of high frequency oscillations (HFOs) in animal models of Alzheimer’s disease (AD). Intra-hippocampal and cortical surface EEG was used to record brain activity during wakefulness, slow wave sleep, and rapid eye movement (REM) sleep. Hippocampal and cortical HFOs were found in all three separate mouse models of AD, but in no controls. HFOs occurred most frequently during slow wave sleep. EEG was also recorded in mouse models of epilepsy to compare the HFOs with those seen in the AD models, and they were found to be indistinguishable. This is the first description of a new EEG biomarker in AD mouse models and future research aims to see if this work can be translated into humans. Dr Lisgaras explains the importance of collaborating with clinicians to investigate the presence of HFOs in patients with AD undergoing routine EEG monitoring. This interview took place at the 14th European Epilepsy Congress (EEC) 2022 in Geneva, Switzerland.
