Sharon K. Inouye, MD, MPH, Hebrew SeniorLife / Harvard Medical School, Boston, MA, introduces the inter-relationship between delirium and Alzheimer’s disease and related dementias (AD/ADRD), as a growing evidence base supports the presence of shared pathophysiologic linkages between the two. Delirium is an acute disturbance in attention and cognition, with significant associated morbidity and mortality. It most often affects hospitalized older adults and is an independent risk factor for subsequent dementia. A significant association has been demonstrated between the presence of delirium and worsened cognitive trajectories, both in individuals with dementia and those without. Additionally, dementia is the leading risk factor for delirium. Prof. Inouye outlines epidemiologic, neuropathologic, and biomarker evidence linking delirium and AD/ADRD. This interview took place at the Alzheimer’s Association International Conference (AAIC) 2022 in San Diego, CA.
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