AMPK in Alzheimer’s Disease: a double-edged sword?

Grahame Hardie, FRS, FRSE, FMedSci, of the University of Dundee, Dundee, UK, gave a talk at the Alzheimer’s Research UK (ARUK) Conference 2018, held in London, UK, about the possible protective role of the AMP-activated kinase (AMPK) pathway on neurodegenerative diseases, such as Alzheimer’s disease. This is a complex issue, however, since contradictory research also exists, which implicates AMPK as a Tau protein kinase, suggesting it has a detrimental effect on the progression of such diseases. Prof. Hardie discusses context-dependent variables that may contribute to this confusing issue.

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