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AAIC 2021 | What underlies the manifestation differences seen in atypical AD?

Lea Grinberg, MD, PhD, Weill Institute for Neurosciences and Memory and Aging Center, University of California, San Francisco, CA, discusses how it is possible that atypical Alzheimer’s disease (AD) cases have the same core defining pathology as typical cases but different clinical manifestation. Dr Grinberg talks on research that has shown that the amount of tau inclusions in specific brain regions is higher in atypical cases than the same regions in typical AD. This finding is suggestive of differences in selective neuronal vulnerability in atypical AD. This interview took place during the Alzheimer’s Association International Conference (AAIC) 2021.