There is almost always a reduction in cerebral oxygenation in the human brain afflicted with Alzheimer’s disease. Seth Love, MBBCh, PhD, MRCP/FRCP, MRCPath/FRCPath, of University of Bristol, Bristol, UK, discusses this and his research investigating the measurement of oxygenation within the brain as well as other aspects of the cerebral tissue at the Alzheimer’s Research UK (ARUK) Conference 2019, held in Harrogate, UK.