Speaking from the Alzheimer’s Association International Conference (AAIC) 2018, held in Chicago, IL, Pieter Jelle Visser, MD, PhD, of VU University Medical Center, Amsterdam, Netherlands, discusses his work on cognitively healthy, elderly monozygotic twins, which investigated amyloid aggregation. This work uncovered interesting results, with ~50% similarity between twins, indicating that around half of the changes are due to environmental differences rather than genetics. Dr Visser highlights the potential impacts of these findings, with opportunities for futher study and lifestyle interventions.