Cynthia Lemere, PhD, from Harvard Medical School, Boston introduces the U.S.POINTER Study and other developing projects at the Alzheimer’s Association International Conference (AAIC) 2017, London, UK. She introduces exciting presentations on the in vivo spreading pathways of tau and amyloid accumulation and its genetic underpinnings, the plasma beta-amyloid test, the impact of amyloid PET on patient management and the U.S POINTER Study.