Neuroinflammatory insults and neurodenegeration

Cynthia Lemere, PhD, from Harvard Medical School, Boston, MA tells us her personal highlight from the Alzheimer’s Association International Conference (AAIC) 2017, London, UK. She is particularly interested in neuroinflammation and how this plays a role in Alzheimer’s disease (AD). She explains how different immune genes are linked to the increased risk of AD. She has done some work on the complement system and increased risk of AD whereby complement can cause neurodegeneration. Complement also appears to have an additional negative effect on synapses and neurons, particularly when released during the glial response to amyloid plaques. Accumulation of these neuroinflammatory insults overtime may lead to memory loss and contribute to the onset of AD.

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