Silvia Anderle, PhD, from University College London, London, UK presents her research which highlights the impact of the APOE4 gene on neurovascular coupling prior to and following the onset of Alzheimer’s disease (AD). Animal studies have shown that the presence of the APOE4 allele causes impaired neurovascular coupling, leading to reduced blood flow and oxygen supply to neurons, and reduced neuronal activation. This vascular dysfunction occurs even before the development of AD pathology, such as amyloid beta (Aβ) plaques. The study also found that Aβ further impairs vascular function, exacerbating the effects in individuals with the APOE4 genotype, when compared to individuals with the APOE3 genotype. Dr Anderle highlights the importance of developing early interventions to address vascular dysfunction in individuals carrying the APOE4 gene, as it could significantly impact future cognitive function. This interview took place at The BNA 2023 International Festival of Neuroscience in Brighton, UK.
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