Katie Lunnon, PhD, PGCAP, of the University of Exeter, Exeter, UK, discusses the DNA methylation changes that occur across a region of the genome spanning the HOXA gene cluster, which are associated with Alzheimer’s disease neuropathology. Dr Lunnon highlights the next steps for study in this area. This interview took place at the Alzheimer’s Research UK (ARUK) Conference 2019, held in Harrogate, UK.