Vladimir Hachinski, MD, DSc, FAAN, Western University, Ontario, Canada, discusses the critical importance of prioritizing research into dementia prevention. The incidence of dementia is decreasing in some high-income countries, but it is not clear why. Identifying the protective factors underlying the prevention of these cases is crucial, so the lessons can be widely applied. Prof. Hachinski introduces the comprehensive, customized, cost-effective approach (CCCAP) to prevention of dementia, which aims to consider all relevant factors (environmental, socioeconomic, and individual risk and protective factors) in a manner which is both cost effective and tailored to prioritize most influential factors in a given area. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.