Celeste Karch, PhD, of Washington University in St. Louis, St. Louis, WA, works on stem cell models to identify genes that are affected by rare mutations of MAPT that are found in frontotemporal dementia (FTD). Here, she discusses coupling her data with bioinformatics and publicly available datasets to illuminate the relationship between MAPT mutations, dysfunction in other pathways like presynaptic signaling and GABA receptors, and disease phenotype and pathology. This video was recorded at the Alzheimer’s Association International Conference (AAIC) 2018, held in Chicago, IL.