Clive Ballard, University of Exeter Medical School, Exeter, UK, discusses how the treatment of Alzheimer’s disease should start earlier as changes in the brain can occur before the onset of symptoms. There has been a significant focus on drug treatments removing or reducing amyloid accumulation in the brain. However, more treatment options should be evaluated. Prof. Ballard concludes that perhaps there has been an overfocus on amyloid and that a broader approach is needed. Further, he talks about mental health as a risk factor for Alzheimer’s and how this can be managed when considering treatment. This interview was recorded on an online conference call with The Video Journal of Dementia (VJDementia).