Charlotte Teunissen, PhD, VU University Medical Center Amsterdam, Amsterdam, The Netherlands, comments on the potential contribution of plasma biomarkers for a reliable and accurate diagnosis of Alzheimer’s disease. Rapid progress has been made in recent years, with data accumulating to support the clinical value of several plasma biomarkers, including phosphorylated tau (p-tau) isoforms, amyloid beta (Aβ) isoforms, GFAP, and neurofilament light (NfL). Dr Teunissen discusses where these markers are likely to fit in the diagnostic work up of Alzheimer’s disease, highlighting that it is too early to rely solely on plasma biomarkers for diagnosis. This interview took place at the AD/PD™ 2022 Conference in Barcelona, Spain.