Jorge Sepulcre, MD, PhD from Massachusetts General Hospital and Harvard Medical School, Boston, MA provides an overview of his work on the amyloid and tau spreading pathways in the brain and its genetics. His work looked into how tau and amyloid deposits spread over time and found that they appear to accumulate long distinct pathways in the brain, pathways we use for daily function. He has also looked at gene expression to determine specific genetic traits that make people vulnerable to tau and amyloid deposits, and believes that this is the pathogenic basis for spreading pathways. This will eventually help in terms of therapeutics, as genetic vulnerability and the ability to determine spreading pathways should aid in decisions regarding which patients should get which therapies and the best time to take them. This video was recorded at the press briefing at the Alzheimer’s Association International Conference (AAIC) 2017, London, UK
