Amy Monaghan, from the Alzheimer’s Research UK UCL Drug Discovery Institute, London, UK, gives a brief outline of her presentation at the Alzheimer’s Research UK (ARUK) Conference 2018, held in London, UK, where she discussed the phenotypic screens that are currently being offered at the institute, and the different areas of research for Alzheimer’s disease and other dementias, including Wnt signaling, synaptic dysfunction and proteostasis.