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AD/PD 2023 | Best outcome measures for Alzheimer’s disease follow-up in the clinic

The tests and scales used in memory clinics to follow patients with cognitive impairment are very variable. In an effort to guide clinicians on the most important outcomes to measure and the optimal measurement instruments, an inter-societal consensus was published on outcome measures for Alzheimer’s disease. Priority outcomes and outcome measures were ranked across several key domains, including cognitive abilities, functional ability, behavioral and neuropsychiatric symptoms, and quality of life. Giovanni Frisoni, MD, University of Geneva, Geneva, Switzerland, explains the need for such guidelines and describes the main agreements reached. This interview took place at the AD/PD™ 2023 congress in Gothenburg, Sweden.

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Transcript (edited for clarity)

This was an international collaboration with a number of scientific societies and stakeholders to identify tools, scales, and cognitive tests to be used in the clinic to follow up patients who are coming for follow up consultations in memory clinics. So these are the traditional patients who get a diagnosis at baseline and then they come every six to 12 to 18 months for a follow up examination. And the tests and scales that are carried out are extremely variable...

This was an international collaboration with a number of scientific societies and stakeholders to identify tools, scales, and cognitive tests to be used in the clinic to follow up patients who are coming for follow up consultations in memory clinics. So these are the traditional patients who get a diagnosis at baseline and then they come every six to 12 to 18 months for a follow up examination. And the tests and scales that are carried out are extremely variable. Every memory clinic has their own standards. Some use the MMSE, some use the MoCA, some don’t use anything, some use a clock drawing test, some use depression and anxiety scales, and whatnot. And the aim of the project was to find a consensus on what scales should be used in the first place for follow-up assessment. And there was some moderate convergence on the use of MoCA in the milder patients and the MMSE in the moderate patients.

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