Alzheimer’s disease (AD) can show great levels of variability in pathology between patients. Bradford Dickerson, MD from Massachusetts General Hospital / Harvard Medical School, Boston, MA discusses the messages which emerged from a session into the heterogeneity of AD, and talks about what the results of his recent work suggest about the disease pathology. This interview was recorded at the 2017 Alzheimer’s Association International Conference (AAIC) held in London, UK.